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Monday, March 25, 2013
Windows Blue Leak Reveals Snap View Side-by-Side Apps, Different Live Tile Sizes, IE 11
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Senate Democratic budget extends standoff with GOP
WASHINGTON (AP) ? An exhausted Senate gave pre-dawn approval Saturday to a Democratic $3.7 trillion budget for next year that embraces nearly $1 trillion in tax increases over the coming decade but shelters domestic programs targeted for cuts by House Republicans.
While their victory was by a razor-thin 50-49 vote, it allowed Democrats to tout their priorities. Yet it doesn't resolve the deep differences the two parties have over deficits and the size of government.
Joining all Republicans voting no were four Democrats who face re-election next year in potentially difficult races: Sens. Max Baucus of Montana, Mark Begich of Alaska, Kay Hagan of North Carolina and Mark Pryor of Arkansas. Sen. Frank Lautenberg, D-N.J., did not vote.
White House spokesman Jay Carney praised the Senate plan, saying in a statement it "will create jobs and cut the deficit in a balanced way."
While calling on both sides to find common ground, Carney did not hold out much hope for compromise with Republicans. The rival budget passed by the GOP-led House cuts social programs too deeply, he said, and fails "to ask for a single dime of deficit reduction from closing tax loopholes for the wealthy and well-connected."
The Senate vote came after lawmakers labored through the night on scores of symbolic amendments, ranging from voicing support for letting states collect taxes on Internet sales to expressing opposition to requiring photo IDs for voters.
Final approval came at around 5 a.m. EDT, capping an extraordinary 20 hours of votes and debate. As the night wore on, virtually all senators remained in the chamber, a rarity during a normal business day. But at that hour, most had nowhere else to go.
The Senate's budget would shrink annual federal shortfalls over the next decade to nearly $400 billion, raise unspecified taxes by $975 billion and cull modest savings from domestic programs.
In contrast, a rival budget approved by the GOP-run House balances the budget within 10 years without boosting taxes.
That blueprint? by House Budget Committee Chairman Paul Ryan, R-Wis., his party's vice presidential candidate last year ? claims $4 trillion more in savings over the period than Senate Democrats by digging deeply into Medicaid, food stamps and other safety net programs for the needy. It would also transform the Medicare health care program for seniors into a voucher-like system for future recipients.
"We have presented very different visions for how our country should work and who it should work for," said Senate Budget Committee Chairman Patty Murray, D-Wash.
The long debate got testy at times.
As the clock ticked past 1 a.m., Murray asked senators to show respect for colleagues "who may not be able to stand as long as us, or who are elderly." Sen. David Vitter, R-La., shot back that Republicans were not trying to delay anything, and wondered what flights or other appointments would be missed if senators voted until 7 a.m.
The loudest acclaim came toward the end, when senators rose as one to cheer a handful of Senate pages ? high school students ? for their work in the chamber since the morning's opening gavel. Senators then left town for a two-week spring recess.
Congressional budgets are planning documents that leave actual changes in revenues and spending for later legislation, and this was the first the Democratic-run Senate has approved in four years. That lapse is testament to the political and mathematical contortions needed to write fiscal plans in an era of record-breaking deficits, and to the parties' profoundly conflicting views.
Republicans said the Democratic budget wasn't much of an accomplishment. "The only good news is that the fiscal path the Democrats laid out...won't become law," said Senate Republican Leader Mitch McConnell of Kentucky.
"I believe we're in denial about the financial condition of our country," Sen. Jeff Sessions of Alabama, top Republican on the Budget panel, said of Democratic efforts to boost spending on some programs. "Trust me, we've got to have some spending reductions."
Though budget shortfalls have shown signs of easing slightly and temporarily, there is no easy path for the two parties to find compromise ? which the first months of 2013 have amply illustrated.
Already this year, Congress has raised taxes on the rich after narrowly averting tax boosts on virtually everyone else, tolerated $85 billion in automatic spending cuts, temporarily sidestepped a federal default and prevented a potential government shutdown.
By sometime this summer, the government's borrowing limit will have to be extended again ? or a default will be at risk ? and it is unclear what Republicans may demand for providing needed votes. It is also uncertain how the two parties will resolve the differences between their two budgets, something many believe simply won't happen.
Both sides have expressed a desire to reduce federal deficits. But President Barack Obama is demanding a combination of tax increases and spending cuts to do so, while GOP leaders say they won't consider higher revenues but want serious reductions in Medicare and other benefit programs that have rocketed deficits skyward.
Obama plans to release his own 2014 budget next month, an unveiling that will be studied for whether it signals a willingness to engage Republicans in negotiations or play political hardball.
The amendments senators considered during their long day of debate were all nonbinding, but some delivered potent political messages.
They voted in favor of giving states more powers to collect sales taxes on online purchases their citizens make from out-of-state Internet companies, and to endorse the proposed Keystone XL pipeline that is to pump oil from Canada to Texas refineries.
They also voiced support for eliminating the $2,500 annual cap on flexible spending account contributions imposed by Obama's health care overhaul and for charging regular postal rates for mailings by political parties, which currently qualify for the lower prices paid by nonprofits.
In a rebuke to one of the Senate's most conservative members, they overwhelmingly rejected a proposal by Sen. Rand Paul, R-Ky., to cut even deeper than the House GOP budget and eliminate deficits in just five years.
The Democratic budget's $975 billion in new taxes would be matched by an equal amount of spending reductions coming chiefly from health programs, defense and reduced interest payments as deficits get smaller than previously anticipated.
This year's projected deficit of nearly $900 billion would fall to around $700 billion next year and bottom out near $400 billion in 2016 before trending upward again.
Shoehorned into the package is $100 billion for public works projects and other programs aimed at creating jobs.
__
Associated Press writer Andrew Taylor contributed to this report.
___
Follow Alan Fram on Twitter: https://twitter.com/asfram
Source: http://news.yahoo.com/senate-democratic-budget-extends-standoff-gop-152340894--politics.html
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Wednesday, March 20, 2013
Kryptonite for cancer cells | news @ Northeastern
June 27, 2012 - Mansoor Amiji, Distinguished Professor and Chair of the Department of Pharmaceutical Sciences at Northeastern University. Amiji's field of expertise includes Drug Delivery and Nanomedicine, the application of nanotechnology for medical diagnosis, imagining, and therapy.
Every avail?able cancer drug is sus?cep?tible to resis?tance, according to Man?soor Amiji, Dis?tin?guished Pro?fessor and chair of the Depart?ment of Phar?ma?ceu?tical Sci?ences. Tumors grow more quickly than blood ves?sels, so these unruly masses of cells receive very little oxygen and nutri?ents, which means they know just how to sur?vive under harsh con?di?tions. They make minia?ture pumps to actively dispel any?thing that doesn?t serve them well (like drugs), and they evade all the checks and bal?ances that nor?mally main?tain healthy cell populations.
Each of these super?cell powers is coded in the cancer?s DNA. In theory, turning off the right genes would turn off the super?powers, according to Amiji. A method called RNA inter?fer?ence does exactly that. By inhibiting pro?tein pro?duc?tion of spe?cific sec?tions of DNA, so-??called small inter?fering RNA, or siRNA, can shut down the activity of indi?vidual?genes.
But this is easier said than done. The siRNA mol?e?cules are incred?ibly finicky mol?e?cules, which Amiji likened to a picky house?guest who needs every?thing just so. ?They?re small, neg?a?tively charged, and extremely labile,? he said, and they degrade if you so much as breathe on them in the lab. All of these char?ac?ter?is?tics make it dif?fi?cult to get them where you want them inside the?body.
In a recent paper in the journal Bio?ma?te?rials, Amiji and col?lab?o?ra?tors at Novartis Insti?tutes for Bio?med?ical Research present a system that they believe will over?come some of these chal?lenges. Using their exper?tise in tar?geted drug delivery, Amiji?s team devel?oped a mod?ular system that can be used to deliver siRNA and any stan?dard drug directly to the cancer cells and nowhere else. This work is funded by the National Cancer Institute?s Alliance for Nan?otech?nology in Cancer Plat?form Part?ner?ship?grant.
?If we really want to take resis?tance head on, we need to address it in a mul?ti?fac?to?rial way,? said Amiji. The new mod?ular system is just that?a mul?ti?fac?eted approach that simul?ta?ne?ously addresses chemo tox?i?city and resis?tance, two of the most dif?fi?cult chal?lenges facing cancer drug developers.
In the research, spear?headed by Amiji?s former grad?uate stu?dent Shanthi Ganesh and cur?rent research assis?tant pro?fessor Arun Iyer, the team cre?ated a library of car?rier com?plexes, each spe?cial?ized for cer?tain prop?er?ties. Some of the com?plexes are good at car?rying neg?a?tively charged mol?e?cules (like siRNA) through the neg?a?tively charged cell mem?brane, which nor?mally repels them. Other com?plexes are good at engulfing hydrophobic drugs (which don?t dis?solve in water), while still others work better with hydrophilic, or
water-??loving,? drugs.
?It?s almost like Lego pieces that you can mix and match to create the right assembly for the right type of pay?load, and then sub?se?quently target the right area of the body where it needs to be deliv?ered,? said?Amiji.
The assem?blies also dawn mol?e?cules that make them act like homing-??pigeons in the blood, car?rying their mes?sages of cel?lular destruc?tion to cancer cells?alone.
In this research, Amiji?s team focused on a mol?e?cule called hyaluronic acid, which many cancer cells rec?og?nize via spe?cial?ized recep?tors on their sur?face. In the lab, they were able to design sys?tems that deliv?ered drugs and siRNAs directly and solely to cancer cells, wherein 100 per?cent of the pay?load was released.
But once they tested the process in live mice, they had less suc?cess. That?s because two fac?tors that help ensure the com?plexes will reach their target aren?t an issue in the petri dish: plumbing and instruc?tions. If the tar?geted cancer cells have too few recep?tors on their sur?face, the com?plexes won?t find them in the rel?a?tively enor?mous organ?ismal system. But even if receptor expres?sion is high, blood supply must also be high in the live mouse, or they won?t even begin their journey in the first?place.
Future researchers will need to bal?ance these fac?tors when using the team?s library to develop car?riers appro?priate for spe?cific drugs and cancer types, Amiji said. But the mod?u?larity of their system makes it espe?cially well-??suited to deal with a variety of unique chal?lenges. ?It allows us to cus?tomize this system for the right type of tumor,? he explained.
View selected pub?li?ca?tions of Man?soor Amiji in IRis, Northeastern?s dig?ital?archive.
Source: http://www.northeastern.edu/news/2013/03/kryptonite-for-cancer-cells/
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Tuesday, March 19, 2013
GOP report calls for sweeping reforms to compete
By Michael O'Brien, Political Reporter, NBC News
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The Republican National Committee released an audacious set of recommendations on Monday aimed at revitalizing the party following the drubbing suffered by GOP candidates last November, calling for sweeping changes to the party's infrastructure, outreach and nominating process to contend for the White House in 2016.
The RNC's 100-page report, the "Growth and Opportunity Project," is the election autopsy ordered by Chairman Reince Priebus last fall.
Handout / Getty Images
Chairman of the Republican National Committee, Reince Priebus, appears on ''Face the Nation'' on March 17, 2013 in Washington, D.C.
Culled from more than 52,000 contacts with voters, party consultants and elected officials, it calls for drastic changes to almost every major element of the modern Republican Party.
"When Republicans lost in November, it was a wake-up call. And in response I initiated the most public and most comprehensive post-election review in the history of any national party," Priebus was set to say in remarks Monday morning at the National Press Club. "As it makes clear, there?s no one reason we lost. Our message was weak; our ground game was insufficient; we weren?t inclusive; we were behind in both data and digital; our primary and debate process needed improvement."
In essence, the report argues for a more data-driven Republican Party in which the RNC assumes increased authority for party-building efforts.
The report calls for increased outreach to women, young voters and minorities ? especially Hispanics. The document acknowledges the GOP?s policy on immigration has become a ?litmus test? for what will be a key constituency?necessary for the party?s success in the next four years and beyond.
"We are not a policy committee, but among the steps Republicans take in the Hispanic community and beyond, we must embrace and champion comprehensive immigration reform," the report says, nodding at other points to the bipartisan reform efforts currently before Congress. "If we do not, our Party?s appeal will continue to shrink to its core constituencies only."
The report also notes a growing generational divide on the issue of gay rights, calling the issue a "gateway" for young voters deciding whether to align with the GOP.
But the report is hardly focused on social issues alone. Its top recurring theme arguably involves building a robust Republican data infrastructure, and applying a commitment to testing and analysis of almost every operation of the RNC.
Priebus is advised to hire a chief technology officer and digital officer by the end of April, and give them wide latitude to inform aspects of the party from fundraising to media strategy and messaging and beyond.
"Those teams will work together to integrate their respective areas throughout the RNC and provide a data-driven focus for the rest of the organization," Priebus will say. "And they will be the new center of gravity within the organization."
The GOP's digital revamp ? as with most of the other elements of the report ? was prompted by the Obama campaign's far more sophisticated operation in 2012.
Many of the reforms proposed by the Growth and Opportunity Project, however, will encounter stiff resistance in corners of the Republican Party and broader conservative movement ? because of a deep distrust of the official GOP among the grassroots.?
Former Alaska Gov. Sarah Palin encapsulated the sentiment during her speech on Saturday before the Conservative Political Action Conference.?
"Now is the time to furlough the consultants, and tune out the pollsters, send the focus groups home, and toss the political scripts," she said, "because if we truly know what we believe, we don't need professionals to tell us."
And some of the report's declarations are sure to ruffle feathers on the Right.
The report says bluntly at one point that "third-party groups that promote purity are hurting our electoral prospects," an indirect reference to groups like the Club for Growth, which has promoted challenges to Republicans regarded as more electable who are accused of transgressing against conservative principle.
The report also calls super PACs a "wild card" that threaten to weaken an eventual nominee due to the onslaught of negative advertising during primaries. (2012 Republican presidential nominee Mitt Romney suffered from this type of friendly fire during his slog to the nomination.)
The report calls for broader changes to the Republican primary system, too, especially as it relates to picking a presidential candidate. It calls for prohibiting primary debates before Sept. 1, 2015, and limiting the total number of debates to 10 or 12 -- and possibly docking delegates from candidates who ignore the rules.
The report also calls for holding the Republican National Convention in late June or July, necessitating that the primary process concludes between late April and mid-May.?
To accomplish that, the Growth and Opportunity Project recommends for a major ??and likely contentious ? overhaul to the primary calendar in which groups of states in a similar region would vote on the same date. The so-called "regional primary system" would follow traditional nominating contests in states like Iowa and New Hampshire, for which there would be an exception.?
Furthermore, the report recommends that Republicans ditch caucuses and conventions ??venues in which conservative activists traditionally dominate ??in favor of primaries for picking a nominee.
Among the report's assorted other recommendations:
- Establish a new "Growth and Opportunity Inclusion Council" tasked with reaching out to Hispanics, African Americans, Asians and Pacific Islanders, Native Americans and other minority communities;
- Commit an initial $10 million to improving outreach to minority communities;
- Set up an "RNC Celebrity Task Force of personalities in the entertainment industry" to attract young voters, and encourage Republican leaders to "participate in and actively prepare for interviews" on the Daily Show, the Colbert Report and other media aimed toward younger Americans;
- Place a greater emphasis on early voting in political strategy, messaging and budgeting;
- Invest in full-time field staff in states beginning at a much earlier point in election cycles;
- Convene a quarterly summit of Republican pollsters, ensure an accurate model of likely voters and turnout for polling, and recommend that GOP polls include a 25 percent subsample of respondents who can be reached by cell phone only;
- Explore making more efficient television advertising purchases, including possibly shifting resources away from paid media and toward organizational efforts and alternative methods of voter contact;
- Work with outside conservative groups (to the extent that it's legal) to better define different organizations' responsibilities;
- Encourage a well-funded conservative group (akin to Democrats' group, American Bridge) dedicated to full-time tracking and research of Democratic candidates;
- Expand the RNC's low-dollar fundraising program, and seek more efficient finance staffing;
- "Convince Congress to remove the biennial aggregate contribution limits," or, absent that, seek to increase the contribution limits for federal campaigns;
- Abolish the public financing system for presidential campaigns, including the matching funds program;
- Replace taxpayer funding of national party conventions with a system in which party committees could raise additional funds for the conventions;
- Allow party committees to raise additional funds to support the maintenance of their buildings and facilities.
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Don't fear 'The Daily Show' and other ways Republicans went wrong in 2012
Growth & Opportunity Project
Within a month after last year's presidential election, the Republican National Committee launched a massive project to diagnose the problems that contributed to the party's defeat. Now, the final draft of the "Growth and Opportunity Project" is here and, as promised, it's a behemoth.
The RNC on Monday released the findings of the three-month project led by a group of veteran Republican strategists that propose ways the party can improve its outreach to minorities, the primary election process, messaging, fundraising and its relationship with third-party groups.
The dense, 100-page report includes 219 recommendations that are a result of input from about 36,000 online surveys, thousands of conference calls and personal meetings with the project's co-chairs, more than 50 focus groups, 3,000 listening sessions in nine states and the District of Columbia and surveys targeting the views of women, Hispanics, pollsters, consultants, campaign volunteers and field staff.
Below are 10 lessons the Republican Party learned from its exhaustive search--and what they plan to do about it.
1. Sustain outreach to minority communities, even in years without elections
From the report:
We need to do a better job connecting people to our policies. Our ideas can sound distant and removed from people?s lives. Instead of connecting with voters? concerns, we too often sound like bookkeepers ... If we believe our policies are the best ones to improve the lives of the American people, all the American people, our candidates and office holders need to do a better job talking in normal, people-oriented terms and we need to go to communities where Republicans do not normally go to listen and make our case. We need to campaign among Hispanic, black,Asian, and gay Americans and demonstrate that we care about them, too.
The RNC will devote $10 million to hire hundreds of new employees in communities across the country who will have a permanent presence. The project will focus on neighborhoods with heavy black, Hispanic and Asian populations to sustain relationships with those communities in years with and without elections and establish new, senior level advisory councils for those voters.
The party is also preparing an "aggressive marketing campaign" at historically black colleges and universities.
2. Recruit more minority Republican candidates
The RNC is launching an ambitious campaign that partners with state parties to build a recruitment program for minority candidates. The party also will hire communication specialists to work with Republican minority leaders to maximize their voice in the media.
3. Don't be afraid of going on The Daily Show
To better reach young voters, the report recommends that Republicans get their candidates on more shows in popular culture and tap into the power of celebrity endorsements.
From the report:
Establish an RNC Celebrity Task Force of personalities in the entertainment industry to host events for the RNC and allow donors to participate in entertainment events as a way to attract younger voters. ... Republican leaders should participate in and actively prepare for interviews with The Daily Show, The Colbert Report, MTV and magazines such as People, UsWeekly, etc., as well as radio stations that are popular with the youth demographic.
4. Give Democratic candidates hell, and dish it early
One of President Barack Obama's re-election campaign's greatest successes was defining Republican presidential candidate Mitt Romney early in the election. It was very difficult for Romney to shake that image of him as an out-of-touch rich boss by the time the Obama campaign was done with him.
The report recommends establishing an outside group "that focuses solely on research" of Republican opponents to "define Democrats early in election cycles." They want to see conservative groups tracking Democratic candidates' every move, while building websites that do "nothing but post inappropriate Democrat utterances and act as a clearinghouse for information on Democrats."
5. Train new Republican activists with online and mobile campaign education programs
Republicans will build a mobile voter registration program that makes it easier for voters to register online For those who want to become actively involved in the party, the RNC is overhauling its Political Education Department to teach activists how to better-use voter data and buy political ads on television and online. All of those resources will be made available on the Web.
6. Release the voter data
The Republican Party has billions of pieces of voter data that they plan to make available to friendly venders and campaigns in a way that allows them to create new apps and programs based on the information.
The RNC hopes to integrate voter data into everything it does--from fundraising to door-to-door canvasing--to ensure every decision is more calculated and results are measurable.
The party plans to establish a new field office near Silicon Valley to have close access with tech firms, while holding "hackathons" in "tech-savvy cities" to ensure they remain up to date on the latest technologies.
7. Shrink the primary
If you thought the Republican primary process felt like it lasted forever, well, so did the top brass at the Republican Party. Next time, the RNC will compress the Republican primary season to a few months in 2016 so the candidates don't have to spend so much money and resources battling each other.
8. Hold fewer primary debates
Before Republicans chose a presidential candidate in 2012, they held more than 20 debates. Never again. The RNC will only conduct about a dozen debates that will begin no earlier than September 2015.
"While we were playing footsie debating each other 23 times, what was the other side doing? They were spending potentially hundreds of millions of dollars on data, technology, voter outreach," RNC Chairman Reince Priebus said Sunday on CBS' "Face the Nation. "They were getting the job done."
Indeed, many of the Republican primary candidates' most embarrassing moments occurred on debate stages across the country.
9. Adios August convention
As part of the emphasis on securing a presidential candidate earlier in the primary process, the Republican National Convention will be held in June or July. That will allow the party and the campaign to coordinate sooner and, along with outside groups, help the candidate build more momentum before the November election.
10. Change the tone, but not the message
Republicans believe they have a communication problem, not a message problem. While the Growth and Opportunity Project was never meant to be a policy document, there appears to be no movement in the direction of shifting principles in the near future. ?I don?t think our platform is the issue,? Preibus said during a stop on his listening tour in Iowa earlier this month.
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Video: CBS News: Military Sex Abuse Case Brings Military Law
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Tuesday, March 12, 2013
Eurofins MWG Operon launches SmartSeq -- An innovative DNA sequencing solution for premixed samples
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 12-Mar-2013[ | E-mail |
Share ] Contact: Dr. Jutta Huber
juttahuber@eurofins.com
49-809-282-89930
Eurofins MWG Operon
Ebersberg, Germany, March 12th, 2013 Eurofins MWG Operon, international market leader for custom DNA sequencing services from single reads to complete sequencing projects, has launched a new prepaid solution for premixed samples in tubes: SmartSeq Kit.
Pooling together purified DNA with the appropriate sequencing primer before sending samples off is a common practice by researchers worldwide. The problem that most researchers face is securely sending the right concentrations of their samples to the sequencing facility. The SmartSeq Kit offers all the consumables to conveniently prepare and safely ship premixed samples (mixture of purified DNA with sequencing primer) to Eurofins MWG Operon's core DNA sequencing facility in Ebersberg, Germany.
SmartSeq Kits combine the advantages of the Eurofins MWG Operon online shop features including administration of kits and secure access to sequencing data.The actual ordering process is made simpler since no further order entries are necessary after one single order for a SmartSeq Kit has been placed. The SmartSeq Kit consists of 96 pre-labelled 2D matrix tubes in a pre-barcoded rack for identification, tube lids for secure sealing and a sample preparation guide.
SmartSeq gives researchers the freedom to share the kit's tubes with colleagues granting them access to the sequencing data. An entire SmartSeq Kit can be freely assigned to someone else with all the rights and data access of the kit.
Free sample bags and boxes are available to send samples using the Eurofins MWG Operon free pick-up service or any commercial postal carrier. Upon sample receipt, the sequencing results are available the very next morning in the customer's secure online account and can be retrieved for more than 100 days.
"The SmartSeq Kit is another excellent product from our marketing and IT solutions team which underlines our goal to truly improve the service we provide to our customers", says Bruno Poddevin, Eurofins Senior Vice President, Genomic Services. "We are extremely excited about the launch as we believe that SmartSeq sets a benchmark and brings tangible added value to routine lab work."
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 12-Mar-2013[ | E-mail |
Share ] Contact: Dr. Jutta Huber
juttahuber@eurofins.com
49-809-282-89930
Eurofins MWG Operon
Ebersberg, Germany, March 12th, 2013 Eurofins MWG Operon, international market leader for custom DNA sequencing services from single reads to complete sequencing projects, has launched a new prepaid solution for premixed samples in tubes: SmartSeq Kit.
Pooling together purified DNA with the appropriate sequencing primer before sending samples off is a common practice by researchers worldwide. The problem that most researchers face is securely sending the right concentrations of their samples to the sequencing facility. The SmartSeq Kit offers all the consumables to conveniently prepare and safely ship premixed samples (mixture of purified DNA with sequencing primer) to Eurofins MWG Operon's core DNA sequencing facility in Ebersberg, Germany.
SmartSeq Kits combine the advantages of the Eurofins MWG Operon online shop features including administration of kits and secure access to sequencing data.The actual ordering process is made simpler since no further order entries are necessary after one single order for a SmartSeq Kit has been placed. The SmartSeq Kit consists of 96 pre-labelled 2D matrix tubes in a pre-barcoded rack for identification, tube lids for secure sealing and a sample preparation guide.
SmartSeq gives researchers the freedom to share the kit's tubes with colleagues granting them access to the sequencing data. An entire SmartSeq Kit can be freely assigned to someone else with all the rights and data access of the kit.
Free sample bags and boxes are available to send samples using the Eurofins MWG Operon free pick-up service or any commercial postal carrier. Upon sample receipt, the sequencing results are available the very next morning in the customer's secure online account and can be retrieved for more than 100 days.
"The SmartSeq Kit is another excellent product from our marketing and IT solutions team which underlines our goal to truly improve the service we provide to our customers", says Bruno Poddevin, Eurofins Senior Vice President, Genomic Services. "We are extremely excited about the launch as we believe that SmartSeq sets a benchmark and brings tangible added value to routine lab work."
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-03/emo-emo031113.php
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Monday, March 11, 2013
Watch The Top YouTube Videos Of The Week: Break Dancing, Buzzer Beaters And Big-Ticket Cars
"Are they going to count that?" Yes, they did. (YouTube: GreekSoccer027)
If you're looking to see the most popular YouTube videos of the week, look no further.
We're taken a different tact this week with our usual roundup on YouTube videos. Instead of just rounding up the top videos, we've sifted through the 20 or so most most trending YouTube postings, according to video service's "Charts" tool, and culled the 10 that we think give the best slice of the viral web last week, March 3-9.
So what did the Web go wild over? We're saw some amazing Italian car porn from the Geneva Motor Show, the best 6-year-old dancer in Internet history and the last throes of the "Harlem Shake" (we hope).
Watch the videos that lit the Internet on fire last week below:
"; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });Source: http://www.huffingtonpost.com/2013/03/10/watch-top-youtube-videos-of-the-week_n_2849776.html
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Iran says it will help learn fate of ex-FBI agent
TEHRAN, Iran (AP) ? Iran's foreign minister says his country is ready to help learn the fate of a retired FBI agent who went missing six years ago.
Iranian media on Monday quoted Ali Akbar Salehi as saying that previous information indicates that Robert Levinson is not in Iran.
But Salehi says Iran is ready to cooperate to help clarify how he disappeared.
Levinson, who is from Coral Springs, Florida, disappeared in March 2007 while traveling to the Iranian island of Kish as a private investigator.
Despite years of denials, U.S. officials involved in the case suspect Iran's intelligence service was behind a 54-second video and five photographs of Levinson that were emailed anonymously to his family a few years ago.
Salehi says, however, that U.S. officials know that Levinson is not in Iran.
Source: http://news.yahoo.com/iran-says-help-learn-fate-ex-fbi-agent-114814634.html
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World class golf at Adare Manor in Ireland - Breaking Travel News
One of most renowned destinations in Ireland, Adare Manor Hotel & Golf Resort offers an unsurpassed level of accommodation, service, dining, and a range activities that have earned it a list of prestigious awards and accolades almost as long as its history.
Located on 840 acres of formal gardens, the resort offers a variety of accommodation options, including the architectural masterpiece that is the Manor House, as well as luxury villas and family-friendly townhouses.
An incredible range of outdoor activities, from golfing on a championship course that is considered one of the finest in Ireland to fishing, horseback riding, archery, clay shooting, and falconry recall the lifestyle and leisure pursuits of the country squire who originally built the Manor House.
After a day of vigorous activity, guests can enjoy pampering treatments at the Treatment Rooms and some of the finest dining in Ireland.
Adare Manor was originally built for the Second Earl of Dunraven and his wife, Lady Caroline Wyndham. Begun in 1832, the magnificent structure provided labour for the surrounding villagers during the terrible potato famine that devastated the country during the mid-19th century.
Though Lady Caroline went to great lengths to establish the myth that Adare Manor was planned entirely by her husband without an architect, it is fairly certain today that much of the design work was done by James Pain who, along with AW Pugin and PC Hardwick, had been commissioned to design numerous public buildings and country homes.
The actual construction was supervised by James Connolly, a local mason. Sadly Lord Dunraven did not live to see his dream Manor finished in 1862.
Golf Holidays
Now, however, the property is known around the world as the home of some of the finest golf in Ireland.
The resort features an 18-hole championship course designed by Robert Trent Jones Sr. that has gained international acclaim as one of his finest creations.
The course, which measures 7,453 yards from the championship tees, is a majestic design with rock-walled streams and subtle undulating putting surfaces with the Jones? signature cloverleaf bunkers.
A 14-acre lake dominates the front nine while the back nine is routed through woodland. Adding beauty to all of this, the River Maigue meanders through the course creating a sense of beauty and adding a further challenge.
Spa Breaks
Overlooking the formal gardens and parkland golf course, The Treatment Rooms at Adare Manor were created as a sanctuary for pampering, relaxation and revitalisation. A team of expert therapists provide a full range of massage, body, facial and beauty treatments featuring Elemis spa products.
The Fitness Room is fully equipped with free weights, Nautilus equipment, treadmill, Stairmaster and lifecycles. Adjacent to the Fitness Room and overlooking the River Maigue, is a 15-meter heated indoor swimming pool and steam room, with changing rooms and locker facilities.
Where to Stay
The Manor House guestrooms are the most exclusive accommodation on the resort.
This architectural masterpiece of towers, turrets, and stonework ornamentation surrounded by breathtaking gardens, majestic trees and ruins dates back over eight hundred years and offers the most elegant castle setting imaginable.
The Manor House has 62 rooms in five different categories: one Presidential Suite, four Dunraven Staterooms, eight Staterooms, 34 Deluxe rooms and 15 Standard rooms.
All of the rooms feature unique architectural details, high ceilings, marble bathrooms and are available with either one king sized bed or two queen sized beds. Some of the bedrooms have fireplaces that are works of art in themselves, with hand carved wood and imported tiles and marble from all over the world.
More Information
For more information on visiting Adare Manor head over to the official website.
Recommended
Source: http://www.breakingtravelnews.com/focus/article/world-class-golf-at-adare-manor-in-ireland/
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Obama Attends Daughter's Basketball Game
President Obama tended to his duties as dad Saturday morning, making time to watch his 11-year-old daughter Sasha play in a basketball game in Chevy Chase, Md., just outside Washington, D.C.
In an interview with ESPN last year, the president talked about his second job as a coach for Sasha's team.
"With the girls, they just think of it as dad, that is what dads are supposed to do. They take it for granted," Obama told ESPN's Andy Katz in 2012.
PHOTOS: Malia and Sasha: Oh, How They've Grown!
"But what was fun, this is now the third year that the team has played together, and to see them all develop at different paces, to get better and start thinking as a team and to feel good when the team does well, to pick each other up when something is not going well, you can't beat it," he said, "you can't beat the satisfaction."
Tonight, the president will make his second appearance at the annual Gridiron Club Dinner, an exclusive Washington, D.C. fete featuring prominent journalists and politicians. The president attended the dinner one other time in 2011.
Also ReadSource: http://news.yahoo.com/obama-attends-daughters-basketball-game-174006381--abc-news-politics.html
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Wednesday, March 6, 2013
AGA Protests PokerStars - Online Gambling News
UPDATE: On Tuesday, Forbes? Nathan Vardi reported that Caesars Entertainment approached PokerStars in February with a potential deal to sell Caesars? Rio property in Nevada and the World Series of Poker brand. Here?s the money quote Vardi attributed to Stars spokesman Eric Hollresiser: ?Caesars Entertainment approached PokerStars and offered to sell us certain assets, such as the Rio Casino in Las Vegas. Caesars suggested that this acquisition would give us a better relationship with Caesars and would help PokerStars gain a license in Nevada. PokerStars declined the offer because we had no plans to acquire another casino in the near term.? Caesars has declined comment on Hollreiser?s claim, but if true, it makes the AGA?s actions detailed below appear even more cynical.
The American Gaming Association (AGA) filed a brief on Monday opposing PokerStars? bid for a New Jersey gaming license. The US brick and mortar casino lobby group has informed the state Casino Control Commission and the Division of Gaming Enforcement (DGE) that the world?s largest online poker company is ?a business built on deceit, chicanery and the systematic flouting of US law.? If the DGE chose to award PokerStars a license, ?the integrity of the gaming industry would be gravely compromised.?
PokerStars issued a statement via spox Eric Hollreiser, who said these were matters ?for expert regulators to determine, not self-interested partisans picking a public fight.? PokerStars has signed a deal to acquire the struggling Atlantic Club Casino Hotel in Atlantic City and preserve the jobs of some 2,000+ employees. The deal, which would offer PokerStars an entry point into New Jersey?s fledgling online gambling market, is contingent upon getting the regulatory thumbs-up. But the AGA says Stars squandered the right to hold a gaming license due to its continued presence in the US market after the 2006 passage of the Unlawful Internet Gambling Enforcement Act (UIGEA).
The faded Atlantic Club had been on the market for a few years with no offers before PokerStars stepped up. Should the DGE reject Stars? license bid, the Atlantic Club will go dark. You can look at this two ways. One way would be that the AGA is actively lobbying to put a couple thousand people out of work. Another would be that the AGA truly believes that Stars is a ?criminal enterprise? that engages in ?chronic lawbreaking.?
But the AGA?s filing ? the first time the organization has ever intervened in a licensing process ? is more a reflection of just how badly the casino companies and their European tech allies want to keep Stars out of New Jersey and out of the US. The past few years have seen a flurry of new regulated markets in the Euro zone, and wherever Stars has gone, it has crushed the competition. Former Bwin.party co-CEO Jim Ryan liked to talk about the strength of the PartyPoker brand in the US, but Stars? brand is Hulk strong, especially since last summer?s deal to reunite Full Tilt Poker?s former players with their long-lost deposits. Extremely expensive marketing, but also extremely effective.
The AGA insists that Stars? $731m settlement with the US Department of Justice last summer ? in which the DoJ acknowledged there was no legal impediment to Stars seeking a gaming license ? hasn?t ?altered in any way? the illegality of Stars? pre-Black Friday activities, whether by the laws of New Jersey or the regulations of the DGE. And the AGA wants the DGE to be men and not let their decision be ?influenced by current economic challenges? at the Atlantic Club or Atlantic City as a whole.
BLOODY FOREIGNERS?
State Sen. Jim Whelan ? a key architect of New Jersey?s online gambling legislation ? told the Press of Atlantic City the casinos were ?motivated by greed. They want to keep foreign investors out.? Whelan was partly responsible for eliminating the legislation?s ?bad actor? language, something Whelan says Caesars Entertainment lobbied hard to prevent. ?I?m fed up with these guys and their ?holier than thou? crap.?
You can?t really blame AGA president Frank Fahrenkopf. He?s officially out the door as of June 30, so he won?t be around to feel the wrath if the DGE rejects Stars? bid and the Atlantic Club folds. You also can?t blame the casino companies. Caesars and MGM Resorts have at least two things in common: operations in Atlantic City and red ink on their balance sheets.
In Caesars? case, the debts have been kept well apart from Caesars Interactive Entertainment (CIE), the online gambling subsidiary whose revenues are a closely guarded secret. Caesars is expected to spin CIE into a distinct entity to flog on the open market and thus allow some of Caesars? long-suffering shareholders to cash out while the cashing is good. But before they can put lipstick on that pig, CIE needs to make a good showing in the New Jersey market.
The casino companies have sold online gambling as a possible solution to their financial woes. Woe to them if Stars gets in, claims half the online poker market overnight leaving everybody else fighting long, hard and very expensively for single-digit shares. The AGA?s attack is unwarranted, but understandable. In 1944, Dwight Eisenhower knew that if he could establish a beachhead on French soil, the German army?s fate was sealed. The AGA is determined to halt PokerStars? invasion of the US mainland at the water?s edge.
Views and opinions expressed are those of the Author and do not necessarily reflect those of CalvinAyre.com
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Scientists focus on another Sandy loss _ lab mice
In this Jan. 18, 2013 photo provided by the NYU Langone Medical Center, a researcher holds a laboratory mouse in a research building at the hospital's complex in New York. During Superstorm Sandy on Oct. 29, 2012, a storm surge flooded the basement housing some 7,000 cages of mice used for studying cancer, diabetes, brain development and other health issues. Each cage held up to five of the little rodents, and even four months later, nobody knows exactly how many perished. (AP Photo/New York University)
In this Jan. 18, 2013 photo provided by the NYU Langone Medical Center, a researcher holds a laboratory mouse in a research building at the hospital's complex in New York. During Superstorm Sandy on Oct. 29, 2012, a storm surge flooded the basement housing some 7,000 cages of mice used for studying cancer, diabetes, brain development and other health issues. Each cage held up to five of the little rodents, and even four months later, nobody knows exactly how many perished. (AP Photo/New York University)
In this Jan. 18, 2013 photo provided by the NYU Langone Medical Center, a technician examines mice in order to determine their clinical health in a research building at the hospital's complex in New York. During Superstorm Sandy on Oct. 29, 2012, a storm surge flooded the basement housing some 7,000 cages of mice used for studying cancer, diabetes, brain development and other health issues. Each cage held up to five of the little rodents, and even four months later, nobody knows exactly how many perished. (AP Photo/New York University)
This Jan. 18, 2013 photo provided by the NYU Langone Medical Center shows genetically engineered mice used to model human diseases in a cage with nesting material in a research building at the hospital's complex in New York. During Superstorm Sandy on Oct. 29, 2012, a storm surge flooded the basement housing some 7,000 cages of mice used for studying cancer, diabetes, brain development and other health issues. Each cage held up to five of the little rodents, and even four months later, nobody knows exactly how many perished. (AP Photo/New York University)
NEW YORK (AP) ? It was one of the most dramatic stories from Superstorm Sandy: more than 300 patients including tiny babies safely removed from a flooded New York hospital that lost power. But in a research building at the complex, where thousands of lab mice were kept, the story had a sadder ending.
A storm surge into the basement swamped some 7,000 cages of mice used for studying cancer, diabetes, brain development and other health issues. Each cage held up to five of the little rodents, and even four months later, nobody knows exactly how many perished.
Now, about 50 scientists at the NYU Langone Medical Center are going through the slow process of replacing them. What they lost in a few minutes one terrible night in October will take more than a year to recover, at a cost of tens of millions of dollars.
That's because, for the most part, they can't simply buy the mice off the shelf. Most were tailor-made, engineered to carry specific genetic mutations to mimic human diseases and conditions like autism. Some breeds can be found only in a few labs worldwide. Others were too new to have been shared yet with researchers elsewhere and will take many months or even two years to recreate.
Besides the mice, researchers lost precious specimens and suffered damage to sensitive equipment from the blackouts and flooding from the nearby East River. The 700-bed hospital closed for almost two months; the emergency room is still shut down.
For researcher Sergei Koralov, the flooding meant the loss of about 600 mice. Gone, for example, were his animals that helped illuminate how genetic changes in white blood cells lead to lymphoma and those he used to study what triggers chronic lung inflammation in asthma. An experiment for improving lung function was also washed away.
"I was devastated," he recalls.
Koralov has contacted scientists in the U.S., Switzerland and Germany in an effort to rebuild his mouse colonies. Scientists often share mice with other labs, which comes in handy at a time like this.
But it's not as easy as just shipping mice to New York. The mice at NYU live in a super-clean environment, and those imported from other labs carry a risk of contamination. So scientists use them to create a new generation of animals that are quarantined and checked for germs before they enter their NYU home.
Not all the mice in the basement died in the flood; those in about 600 cages were rescued about a week afterward. Their handlers had put extra food in their cages just in case before the storm. But because of contamination, new generations have to be created from them, too, in sterile surroundings.
When no mice with the right genetic makeup are available, researchers have to start from scratch. Koralov works with mice that have many genetic modifications, perhaps as many as seven per mouse, and recreating such animals can require breeding over half a dozen generations.
In all, he figures it will take two years to recover the most complicated ones. But the storm has given him the chance to take a new look at his research.
"The silver lining of the whole storm, what little there is, is the fact it allows me to refocus myself," he said. Now he can "go after what is interesting to me now, not what was interesting to me two years ago."
Much of the effort to replace the mice is taking place elsewhere. The Jackson Laboratory in Bar Harbor, Maine, which distributes more than 6,000 kinds of modified mice to labs around the world, is working on at least 200 types for the New York researchers, said the lab's Stephen Linnell.
So what can be done to prepare for the next big storm?
At NYU Langone, officials will consider waterproofing strategies for one building that houses mice underground and they are working on "an aggressive evacuation plan," said Dafna Bar-Sagi, the center's vice dean for science.
A new science building is due to open in 2016, with one feature planned even before the storm: It will keep mice on the third floor.
___
Malcolm Ritter can be followed at http://www.twitter.com/malcolmritter
Associated PressEnergy nominee favors all-of the-above approach
WASHINGTON (AP) ? President Barack Obama's choice to lead the Energy Department advocates an all-of-the-above approach to energy and favors natural gas as a "bridge fuel" to reduce emissions that contribute to global warming.
Ernest Moniz, a physics professor at the Massachusetts Institute of Technology, leads the MIT Energy Initiative, a research group that gets funding from BP, Chevron and other oil industry heavyweights for academic work aimed at reducing greenhouse gases blamed for global warming. A former energy undersecretary, Moniz has advised Obama on numerous energy topics, including how to handle the country's nuclear waste and the natural gas produced by the controversial technique of hydraulic fracturing.
"Ernie knows that we can produce more energy and grow our economy while still taking care of our air, our water and our climate," Obama said Monday as he introduced Moniz and two other candidates for top-level positions.
Gina McCarthy, an assistant EPA administrator, was chosen to lead the Environmental Protection Agency. A 25-year veteran of environmental policy and politics, McCarthy has worked for Republicans and Democrats, including Obama's presidential rival, Mitt Romney, who tapped her to help draft state plans for curbing the pollution linked to global warming when he was governor of Massachusetts.
Sylvia Mathews Burwell was nominated to direct the White House Office of Management and Budget. Burwell held several posts during the Clinton administration, including deputy director of the OMB. She currently heads the Wal-Mart Foundation, the philanthropic arm of the retail giant, and previously served as president of the Gates Foundation's Global Development Program.
Moniz, 68, whose specialty is nuclear physics, has drawn fire from some environmental groups for his views on natural gas, especially that produced from shale, a gas-rich rock formation thousands of feet underground. The gas is freed through a process called hydraulic fracturing, or fracking, in which large volumes of water, plus sand and chemicals, are injected to break the rock apart. Advances in technology have unlocked billions of dollars of gas reserves, leading to a boom in production, jobs and profits, as well as concerns about pollution and public health.
At a forum last year at the University of Texas, Moniz said natural gas, which emits fewer greenhouse gases than oil or coal, is likely to be part of the nation's energy solution for years to come.
As a nation, the U.S. "should take advantage of the time to innovate and bring down the cost of renewables," Moniz said. "The worst thing would be to get time and not use it."
Those and other comments have made some environmental groups wary of Moniz, who also has supported development of nuclear power, along with renewable energy sources such as wind and solar.
"Ernest Moniz has a history of supporting dirty and dangerous energy sources like gas and nuclear power with polluting partners including BP, Shell, Chevron and Saudi Aramco," said Courtney Abrams of the group Environment America. "Given this concerning track record, we hope Dr. Moniz will focus on clean, renewable ways to get our energy that don't put our families and our environment in harm's way."
Fred Krupp, president of the Environmental Defense Fund, said Moniz "has recognized that there are environmental issues ? real issues, serious issues ? with natural gas."
When Moniz says issues with natural gas are manageable, "he quickly adds that just because they are manageable doesn't mean they are managed," Krupp said. "To me that's actually a very full understanding that he brings to this role."
As energy secretary, Moniz would not have direct oversight over fracking, which is primarily left to state and local governments. Even so, the Energy Department has a huge research budget, and current Energy Secretary Steven Chu has been criticized for focusing too much on renewables such as wind and solar and not enough on natural gas, which has emerged in recent years as an energy powerhouse that has threatened the dominance of coal, the leading source of electricity in the U.S.
Like Chu, Moniz is an academic with a doctorate in physics. Unlike Chu, who led an Energy Department lab before becoming energy secretary, Moniz has extensive political experience, having served in the Clinton administration as undersecretary of energy and as a White House science adviser.
"The really good thing about Ernie is he's been there, so he can hit the ground running," said Carol Browner, a former Obama energy adviser who worked with Moniz when she headed the Environmental Protection Agency under President Bill Clinton.
John Deutch, an MIT colleague and former CIA director, called Moniz a "brilliant choice" to lead the Energy Department.
"I think that President Obama has chosen the most qualified individual in the United States for the position of secretary of energy," said Deutch, who led a review of shale-gas drilling for the Energy Department in Obama's first term.
Thomas Pyle, president of the Institute for Energy Research, a conservative advocacy group, set his sights a little lower.
If confirmed, Moniz will "inherit an agency with a tarnished record for picking losers and not winners in the energy market," Pyle said. "It is our hope that Dr. Moniz will avoid opportunities to repeat the well-documented mistakes of his predecessor and refuse the temptation to let political pressure trump sound science and economics."
___
Associated Press writer Dina Cappiello contributed to this report.
___
Follow Matthew Daly on Twitter: https://twitter.com/MatthewDalyWDC
Source: http://news.yahoo.com/energy-nominee-favors-above-approach-080411671--politics.html
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